iPSC-derived Vascular Endothelial Cells

Human induced pluripotent stem cells (iPSCs) are a powerful tool for studying endothelial cells in vitro. Human iPS cells overcome many of the limitations of other popular models, such as immortalized cell lines and primary endothelial cells, which can be plagued by reproducibility issues and lack of biological relevance. Although human iPS cells have many advantages over existing models, one drawback is that differentiation into the desired cell type is a time and labor-intensive process. To address this research bottleneck, Elixirgen Scientific provides a variety of products and services to make research more efficient. Our proprietary technology allows for rapid, reproducible differentiation of human iPSC-derived vascular endothelial cells without sacrificing purity. 

Advantages

  • Fast differentiation and maturation
  • Highly pure population
  • No genetic footprint

Applications

  • Basic research
  • Drug screening
  • Disease modeling

Quick-Endo™ Vascular Endothelial Cell Differentiation Kit & Medium

Our Quick-Endothelium™ Vascular Endothelial differentiation kit allows researchers to quickly, easily, and efficiently differentiate their iPS cell line into vascular endothelial cells. 

Cat No.Product NameDescription
VE-mRNA-SQuick-Endothelium™ Vascular - mRNA Kit (Small)This kit differentiates human pluripotent stem cells into vascular endothelial cells in 7 days using mRNA cocktails.
VE-MMQuick-Endothelium™ Vascular - Maintenance MediumThis medium maintains differentiated vascular endothelial cells for up to 2 weeks.

Quick-Endo™ Vascular Endothelial Differentiation Service

Elixirgen Scientific provides stem cell differentiation services with the world’s fastest turnaround time. Our differentiation method provides homogenous cell cultures without a genetic footprint. Researchers can simply ship live iPSCs to us and receive differentiating or terminally differentiated vascular endothelial cells in as little as one week. Each project is unique, so please contact us with your specifications to receive more information or to receive a quote.

Characterization

Quick-Endothelium™ Vascular Endothelial cell cultures express both endothelial and tight junction markers and display typical endothelial morphology. Immunofluorescent staining that shows expression of endothelial markers CD31 and vWF as well as the tight junction marker Claudin-5 on Day 5. Images courtesy of Ricoh.

Representative images of Quick-Endothelium™ Vascular – mRNA Kit cell cultures on days 1-5 post-differentiation (scale bar = 100 μm).