Cholinergic Neurons from Autism Spectrum Disorder (CW20090, F, 18, Asian)

Description

Quantity: ~1M viable cells

CIRM Line ID: CW20090

Disease: Autism Spectrum Disorder

Gender: Female

Sampled age: 18

Race: Asian

Donor data

Demographic (source: CIRM)	Description	AUTISM SPECTRUM DISORDER; ASD
	Affected Status	Yes
	Product	iPSC
	Source	PBMC
	Sex	Female
	Age at Sampling	18 YR
	Race	Asian
	Ethnicity	Not Hispanic or Latino
	Publications Cited	0
	dbGap	No
	Diagnosis Age	3
	Biopsy Source	Blood
	Collection	Neurodevelopmental Disorders
	Cell Type	Stem Cell
	Tissue Type	Induced pluripotent stem cell
	Transformant	Episomal
	Species	sapiens
	Common Name	human
	Detailed Clinical Data	false
Clinical data (source: CIRM)	ASD	ASD
	Number_of_siblings_with_ASD	0
	Symptoms_Present_in_the_First_Year_of_Life	No data
	Communication_-_Verbal	20
	Communication_-_Nonverbal	12
	Restricted_Repetitive_and_Stereotyped_Patterns_of_	6
	Abnormality_of_Development_Evident_at_or_Before_36	4
	Qualitative_Impairment_in_Reciprocal_Social_Intera	29
	ADOS_Test_Used	ADOS 2
	Communication_and_Social	13
	Stereotyped_Behaviors_and_Restricted_Interests	5
	Full_Scale_IQ	40
	Verbal_IQ	43
	Non_Verbal_IQ	40
	Test_used	Stanford Binet
	ASDMedicalFamilyHistory	ASDMedicalFamilyHistory
	Diagnosis	Autism Spectrum Disorder
	Birthweight_(kgs)	3.88
	Birth_order	2
	Number_of_siblings_(includes_half_and_whole_siblin	1
	Weight_%	50
	Height_%	55.88
	Head_Circumference_(cm)	59
	Maternal_age_(years)	54
	Maternal_age_at_delivery_(years)	36
	Paternal_age_(years)	59
	Paternal_age_at_delivery_(years)	41
	Chromosome_test_results	Not Available
	Consanguinity	No

• Users do not need any additional license for the use of these differentiated cells even when cells are used for high throughput screening or drug discovery.
• All donor consents include statements on the following:
• Testing the cells’ DNA (this is referred to as the cell’s genetic code or sequence) and making the information known to other researchers
• Changing some of the genetic code or sequence within these cells
• Using cells to test or select drugs to treat disease
• Transplanting cells or resulting products to humans or animals

  Distributing cells widely (nationally and internationally) for research, training or commercial medical product development

• Future research and uses unforeseen at this time
• Donors were screened and negative for HIV, HBV, and HCV. Donors under the age of 18 could opt out of HIV testing; all HCV-positive donors submitted skin punches, not peripheral blood, and were not screened for any infectious agents due to small volume of blood present in punches.
• Human induced pluripotent stem cells were established by non-integrating episomal reprogramming. Reprogramming and quality control were performed by Cellular Dynamics International.