Cholinergic Neurons from Epilepsy (CW60130, F, 6, Caucasian, not Latino)

Description

Quantity: ~1M viable cells

CIRM Line ID: CW60130

Disease: Epilepsy

Gender: Female

Sampled age: 6

Race: Caucasian, not Latino

Donor data

Demographic (source: CIRM)	Description	EPILEPSY
	Affected Status	Yes
	Product	iPSC
	Source	PBMC
	Sex	Male
	Age at Sampling	6 YR
	Race	Caucasian
	Ethnicity	Not Hispanic or Latino
	Publications Cited	0
	dbGap	No
	Biopsy Source	Blood
	Collection	Neurodevelopmental Disorders
	Remarks	Height percentage < 5%
	Cell Type	Stem Cell
	Tissue Type	Induced pluripotent stem cell
	Transformant	Episomal
	Species	sapiens
	Common Name	human
	Detailed Clinical Data	false
Clinical data (source: CIRM)	Age_at_first_seizure	4
	Age_units	Years
	Age_at_last_seizure	5 years
	Seizure_type	Absence
	Seizures_with_fever?	No
	Seizures_without_fever?	Yes
	Being_treated_for_seizures_now?	Yes
	EEG_findings	Focal sharp waves

• Users do not need any additional license for the use of these differentiated cells even when cells are used for high throughput screening or drug discovery.
• All donor consents include statements on the following:
• Testing the cells’ DNA (this is referred to as the cell’s genetic code or sequence) and making the information known to other researchers
• Changing some of the genetic code or sequence within these cells
• Using cells to test or select drugs to treat disease
• Transplanting cells or resulting products to humans or animals

  Distributing cells widely (nationally and internationally) for research, training or commercial medical product development

• Future research and uses unforeseen at this time
• Donors were screened and negative for HIV, HBV, and HCV. Donors under the age of 18 could opt out of HIV testing; all HCV-positive donors submitted skin punches, not peripheral blood, and were not screened for any infectious agents due to small volume of blood present in punches.
• Human induced pluripotent stem cells were established by non-integrating episomal reprogramming. Reprogramming and quality control were performed by Cellular Dynamics International.