• ipsc excitatory neurons merge


CIRM Line ID: CW20090
Disease: Autism Spectrum Disorder
Gender: Female
Sampled age: 18
Ethnicity: Asian

SKU: EX-SeV-CW20090 Categories: , , Tag:


Elixirgen Scientific’s proprietary transcription factor-based technology allows rapid and reproducible differentiation of human iPSCs into neurons without sacrificing the purity of the cells. Our Quick-Neuron™ Excitatory – Human iPSC-derived Neurons display typical neurite outgrowth and express a variety of neuronal markers, such as the pan-neuronal marker tubulin beta 3 class III (TUBB3) and the glutamatergic neuron marker vesicular glutamate transporter 1 (vGLUT1). When handled and maintained according to the instructions in this user guide, excitatory neurons are viable long-term and are suitable for a variety of characterization and neurotoxicity assays.

Protocol Outline


ipsc excitatory neurons protocol


ipsc excitatory neurons
Quick-Neuron™ Excitatory cultures expressing the pan-neuronal marker TUBB3 and the glutamatergic neuron marker vGLUT1.



User Guides


Donor data

Demographic (source: CIRM) Description AUTISM SPECTRUM DISORDER; ASD
Affected Status Yes
Product iPSC
Source PBMC
Sex Female
Age at Sampling 18 YR
Race Asian
Ethnicity Not Hispanic or Latino
Publications Cited 0
dbGap No
Diagnosis Age 3
Biopsy Source Blood
Collection Neurodevelopmental Disorders
Cell Type Stem Cell
Tissue Type Induced pluripotent stem cell
Transformant Episomal
Species sapiens
Common Name human
Detailed Clinical Data false
Clinical data (source: CIRM) ASD ASD
Number_of_siblings_with_ASD 0
Symptoms_Present_in_the_First_Year_of_Life No data
Communication_-_Verbal 20
Communication_-_Nonverbal 12
Restricted_Repetitive_and_Stereotyped_Patterns_of_ 6
Abnormality_of_Development_Evident_at_or_Before_36 4
Qualitative_Impairment_in_Reciprocal_Social_Intera 29
ADOS_Test_Used ADOS 2
Communication_and_Social 13
Stereotyped_Behaviors_and_Restricted_Interests 5
Full_Scale_IQ 40
Verbal_IQ 43
Non_Verbal_IQ 40
Test_used Stanford Binet
ASDMedicalFamilyHistory ASDMedicalFamilyHistory
Diagnosis Autism Spectrum Disorder
Birthweight_(kgs) 3.88
Birth_order 2
Number_of_siblings_(includes_half_and_whole_siblin 1
Weight_% 50
Height_% 55.88
Head_Circumference_(cm) 59
Maternal_age_(years) 54
Maternal_age_at_delivery_(years) 36
Paternal_age_(years) 59
Paternal_age_at_delivery_(years) 41
Chromosome_test_results Not Available
Consanguinity No
  • Users do not need any additional license for the use of these differentiated cells even when cells are used for high throughput screening or drug discovery.
  • All donor consents include statements on the following:
    • Testing the cells’ DNA (this is referred to as the cell’s genetic code or sequence) and making the information known to other researchers
    • Changing some of the genetic code or sequence within these cells
    • Using cells to test or select drugs to treat disease
    • Transplanting cells or resulting products to humans or animals
      Distributing cells widely (nationally and internationally) for research, training or commercial medical product development
    • Future research and uses unforeseen at this time
  • Donors were screened and negative for HIV, HBV, and HCV. Donors under the age of 18 could opt out of HIV testing; all HCV-positive donors submitted skin punches, not peripheral blood, and were not screened for any infectious agents due to small volume of blood present in punches.
  • Human induced pluripotent stem cells were established by non-integrating episomal reprogramming. Reprogramming and quality control were performed by Cellular Dynamics International.


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Not for medical diagnostic or clinical use. For in vitro use only. By use of this product, the recipient agrees to be bound by the terms of this limited use statement. This product may not be further sold or transferred by the recipient and may be used only by the recipient. Elixirgen Scientific makes no representations or warranties of any kind, either expressed or implied, including as to merchantability or fitness for a particular purpose with regards to this product. The terms of this agreement shall be governed under the laws of the State of Maryland, USA.